Gangrene is a type of tissue death caused by a lack of blood supply. Symptoms may include a change in skin color to red or black, numbness, swelling, pain, skin breakdown, and coolness. The feet and hands are most commonly affected. Certain types may present with a fever or sepsis.
Risk factors include DIabetes, Peripheral arterial disease, Smoking, major trauma, alcoholism, HIV/AIDS, & Raynaud's syndrome.